解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A new virus of halophilic Archaea is reported by Liu et al., and is remarkable in many ways. SNJ2 is the first temperate, pleomorphic virus (pleolipovirus) that integrates into the genome of its host. Analyses of the virus structure and its genome have provided an unexpected puzzle while at the same time solving anoth...
journal_title:Molecular microbiology
pub_type: 评论,杂志文章
doi:10.1111/mmi.13212
更新日期:2015-12-01 00:00:00
abstract::The cereal pathogen Fusarium graminearum threatens food and feed production worldwide. It reduces the yield and poisons the remaining kernels with mycotoxins, notably deoxynivalenol (DON). We analyzed the importance of gamma-aminobutanoic acid (GABA) metabolism for the life cycle of this fungal pathogen. GABA metaboli...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13203
更新日期:2015-12-01 00:00:00
abstract::The Gram-positive pathogen Corynebacterium diphtheriae exports through the Sec apparatus many extracellular proteins that include the key virulence factors diphtheria toxin and the adhesive pili. How these proteins attain their native conformations after translocation as unfolded precursors remains elusive. The fact t...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13172
更新日期:2015-12-01 00:00:00
abstract::Almost all bacterial genomes contain DNA of viral origin, including functional prophages or degenerated phage elements. A frequent but often unnoted phenomenon is the spontaneous induction of prophage elements (SPI) even in the absence of an external stimulus. In this study, we have analyzed SPI of the large, degenera...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13147
更新日期:2015-11-01 00:00:00
abstract::Bacteriophages are present in virtually all ecosystems, and bacteria have developed multiple antiphage strategies to counter their attacks. Clostridium difficile is an important pathogen causing severe intestinal infections in humans and animals. Here we show that the conserved cell-surface protein CwpV provides antip...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13121
更新日期:2015-10-01 00:00:00
abstract::Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13132
更新日期:2015-10-01 00:00:00
abstract::A unique 373 bp region (igr66) between grpE and dnaK of Streptococcus mutans lacks a promoter but is required for optimal production of DnaK. Northern blotting using probes specific to hrcA, igr66 or dnaK revealed multiple transcripts produced from the dnaK operon and 5'-RACE mapped 5' termini of multiple dnaK transcr...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13122
更新日期:2015-10-01 00:00:00
abstract::Effector translocation is central to the virulence of many bacterial pathogens, including Streptococcus pyogenes, which utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+) glycohydrolase SPN into host cells during infection. SLO's translocation activity does not require host cel...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13085
更新日期:2015-09-01 00:00:00
abstract::We have identified a phosphate transporter (TcPho91) localized to the bladder of the contractile vacuole complex (CVC) of Trypanosoma cruzi, the etiologic agent of Chagas disease. TcPho91 has 12 transmembrane domains, an N-terminal regulatory SPX (named after SYG1, Pho81 and XPR1) domain and an anion permease domain. ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13075
更新日期:2015-09-01 00:00:00
abstract::Regulation of gene expression in trypanosomatid parasitic protozoa is mainly achieved posttranscriptionally. RNA-binding proteins (RBPs) associate to 3' untranslated regions in mRNAs through dedicated domains such as the RNA recognition motif (RRM). Trypanosoma cruzi UBP1 (TcUBP1) is an RRM-type RBP involved in stabil...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13090
更新日期:2015-09-01 00:00:00
abstract::Calcineurin plays essential roles in virulence and growth of pathogenic fungi and is a target of the natural products FK506 and Cyclosporine A. In the pathogenic mucoralean fungus Mucor circinelloides, calcineurin mutation or inhibition confers a yeast-locked phenotype indicating that calcineurin governs the dimorphic...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13071
更新日期:2015-09-01 00:00:00
abstract::A key component to the success of Mycobacterium tuberculosis as a pathogen is the ability to sense and adapt metabolically to the diverse range of conditions encountered in vivo, such as oxygen tension, environmental pH and nutrient availability. Although nitrogen is an essential nutrient for every organism, little is...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13091
更新日期:2015-09-01 00:00:00
abstract::Several Fusarium species produce the polyketide mycotoxin zearalenone (ZEA), a causative agent of hyperestrogenic syndrome in animals that is often found in F. graminearum-infected cereals in temperate regions. The ZEA biosynthetic cluster genes PKS4, PKS13, ZEB1 and ZEB2 encode a reducing polyketide synthase, a non-r...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13078
更新日期:2015-09-01 00:00:00
abstract::Iron is a member of a small group of nutrients that limits aquatic primary production. Mechanisms for utilizing iron have to be efficient and adapted according to the ecological niche. In respect to iron acquisition cyanobacteria, prokaryotic oxygen evolving photosynthetic organisms can be divided into siderophore- an...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13049
更新日期:2015-08-01 00:00:00
abstract::P1 B -ATPases are among the most common resistance factors to metal-induced stress. Belonging to the superfamily of P-type ATPases, they are capable of exporting transition metal ions at the expense of adenosine triphosphate (ATP) hydrolysis. P1 B -ATPases share a conserved structure of three cytoplasmic domains linke...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13038
更新日期:2015-08-01 00:00:00
abstract::The ability for light sensing is found from bacteria to humans but relies only on a small number of evolutionarily conserved photoreceptors. A large number of fungi react to light, mostly to blue light. Aspergillus nidulans also responds to red light using a phytochrome light sensor, FphA, for the control of hundreds ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13062
更新日期:2015-08-01 00:00:00
abstract::Gram-negative bacteria survive harmful environmental stressors by modifying their outer membrane. Much of this protection is afforded upon remodeling of the lipid A region of the major surface molecule lipopolysaccharide (LPS). For example, the addition of cationic substituents, such as 4-amino-4-deoxy-L-arabinose (L-...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13018
更新日期:2015-07-01 00:00:00
abstract::The pathogenicity of Plasmodium falciparum is partly due to parasite-induced host cell modifications. These modifications are facilitated by exported P. falciparum proteins, collectively referred to as the exportome. Export of several hundred proteins is mediated by the PEXEL/HT, a protease cleavage site. The PEXEL/HT...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13024
更新日期:2015-07-01 00:00:00
abstract::In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions about the function of these rh...
journal_title:Molecular microbiology
pub_type: 评论,杂志文章
doi:10.1111/mmi.13032
更新日期:2015-07-01 00:00:00
abstract::Penicillium chrysogenum is the main industrial producer of the β-lactam antibiotic penicillin, the most commonly used drug in the treatment of bacterial infections. Recently, a functional MAT1-1 locus encoding the α-box transcription factor MAT1-1-1 was discovered to control sexual development in P. chrysogenum. As on...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12987
更新日期:2015-06-01 00:00:00
abstract::Iron availability is a key determinant of virulence in the pathogenic fungus Cryptococcus neoformans. Previous work revealed that the ESCRT (endosomal sorting complex required for transport) protein Vps23 functions in iron acquisition, capsule formation and virulence. Here, we further characterized the ESCRT machinery...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12985
更新日期:2015-06-01 00:00:00
abstract::Numerous eukaryotes have developed specific metabolic traits that are not present in extensively studied model organisms. For instance, the procyclic insect form of Trypanosoma brucei, a parasite responsible for sleeping sickness in its mammalian-specific bloodstream form, metabolizes glucose into excreted succinate a...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1111/mmi.12990
更新日期:2015-06-01 00:00:00
abstract::Rhamnolipid acts as a virulence factor during Pseudomonas aeruginosa infection. Here, we show that deletion of the catabolite repression control (crc) gene in P. aeruginosa leads to a rhamnolipid-negative phenotype. This effect is mediated by the down-regulation of rhl quorum sensing (QS). We discover that a disruptio...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12954
更新日期:2015-05-01 00:00:00
abstract::In cyanobacteria and chloroplasts, exposure to HL damages the photosynthetic apparatus, especially the D1 subunit of Photosystem II. To avoid chronic photoinhibition, a PSII repair cycle operates to replace damaged PSII subunits with newly synthesised versions. To determine the sub-cellular location of this process, w...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12940
更新日期:2015-05-01 00:00:00
abstract::Chemoreceptors play a central role in chemotaxis, allowing bacteria to detect chemical gradients and bias their swimming behavior in order to navigate toward favorable environments. The genome of the kiwifruit pathogen, Pseudomonas syringae pv. actinidiae (Psa) strain NZ-V13 encodes 43 predicted chemoreceptors, none o...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12964
更新日期:2015-05-01 00:00:00
abstract::Helicobacter pylori is a human gastric pathogen that colonizes ∼ 50% of the world's population. It can cause gastritis, gastric or duodenal ulcers and also gastric cancer. The numerous side effects of available treatments and the emergence of antibiotic resistant strains are severe concerns that justify further resear...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12923
更新日期:2015-04-01 00:00:00
abstract::Histidine kinases (HK) sense and transduce via phosphorylation events many intra- and extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread in the fungal kingdom, but their precise roles in the regulation of physiological processes remain largely obscure. Expanding genomic resourc...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1111/mmi.12911
更新日期:2015-03-01 00:00:00
abstract::A transposon insertion screen implicated the yejH gene in the repair of ionizing radiation-induced damage. The yejH gene, which exhibits significant homology to the human transcription-coupled DNA repair gene XPB, is involved in the repair of double-strand DNA breaks. Deletion of yejH significantly sensitized cells to...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12885
更新日期:2015-03-01 00:00:00
abstract::The cytokinetic apparatus of bacteria is initially formed by the polymerization of the tubulin-like FtsZ protein into a ring structure at midcell. This so-called Z-ring facilitates the recruitment of many additional proteins to the division site to form the mature divisome machine. Although the assembly pathway leadin...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12905
更新日期:2015-03-01 00:00:00
abstract::Escherichia coli FtsN is a bitopic membrane protein that is essential for triggering active cell constriction. A small periplasmic subdomain ((E) FtsN) is required and sufficient for function, but its mechanism of action is unclear. We isolated extragenic (E) FtsN*-suppressing mutations that restore division in cells ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12906
更新日期:2015-03-01 00:00:00
abstract::In the yeast Saccharomyces cerevisiae, the regulation of cell types by homeodomain transcription factors is a key paradigm; however, many questions remain regarding this class of developmental regulators in other fungi. In the human fungal pathogen Cryptococcus neoformans, the homeodomain transcription factors Sxi1α a...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12898
更新日期:2015-03-01 00:00:00
abstract::Biosynthesis of fatty acids is one of the most fundamental biochemical pathways in nature. In bacteria and plant chloroplasts, the committed and rate-limiting step in fatty acid biosynthesis is catalyzed by a multi-subunit form of the acetyl-CoA carboxylase enzyme (ACC). This enzyme carboxylates acetyl-CoA to produce ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12912
更新日期:2015-03-01 00:00:00
abstract::In eukaryotes, frataxin deficiency (FXN) causes severe phenotypes including loss of iron-sulfur (Fe-S) cluster protein activity, accumulation of mitochondrial iron and leads to the neurodegenerative disease Friedreich's ataxia. In contrast, in prokaryotes, deficiency in the FXN homolog, CyaY, was reported not to cause...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12888
更新日期:2015-02-01 00:00:00
abstract::Metabolic adaptations are critical to the ability of bacterial pathogens to grow within host cells and are normally preceded by sensing of host-specific metabolic signals, which in turn can influence the pathogen's virulence state. Previously, we reported that the intracellular bacterial pathogen Listeria monocytogene...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12890
更新日期:2015-02-01 00:00:00
abstract::Intimin and Invasin are prototypical inverse (Type Ve) autotransporters and important virulence factors of enteropathogenic Escherichia coli and Yersinia spp. respectively. In addition to a C-terminal extracellular domain and a β-barrel transmembrane domain, both proteins also contain a short N-terminal periplasmic do...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12840
更新日期:2015-01-01 00:00:00
abstract::Type III secretion systems are found in many Gram-negative bacteria. They are activated by contact with eukaryotic cells and inject virulence proteins inside them. Host cell detection requires a protein complex located at the tip of the device's external injection needle. The Shigella tip complex (TC) is composed of I...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12843
更新日期:2015-01-01 00:00:00
abstract::Stimulation of Escherichia coli with acetate elevates the acetylation level of the chemotaxis response regulator CheY. This elevation, in an unknown mechanism, activates CheY to generate clockwise rotation. Here, using quantitative selective reaction monitoring mass spectrometry and high-resolution targeted mass spect...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12858
更新日期:2015-01-01 00:00:00
abstract::Pathogenic enterotoxigenic Escherichia coli (ETEC) are the major bacterial cause of diarrhea in young children in developing countries and in travelers, causing significant mortality in children. Adhesive fimbriae are a prime virulence factor for ETEC, initiating colonization of the small intestinal epithelium. Simila...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12847
更新日期:2015-01-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are persistent and toxic environmental pollutants that accumulate in anoxic habitats. With the exception of naphthalene, nothing is known about the microbial degradation of PAH in these environments. The challenge that must be met in anaerobic PAH degradation is the destabilizat...
journal_title:Molecular microbiology
pub_type: 评论,杂志文章
doi:10.1111/mmi.12874
更新日期:2015-01-01 00:00:00
abstract::Stable RNA maturation is a key process in the generation of functional RNAs, and failure to correctly process these RNAs can lead to their elimination through quality control mechanisms. Studies of the maturation pathways of ribosomal RNA and transfer RNA in Bacillus subtilis showed they were radically different from ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.12863
更新日期:2015-01-01 00:00:00